Küreselleşmeden Maduniyete: Asef Bayat Perspektifi
نویسندگان
چکیده
منابع مشابه
Introducing the Adherence Strategy Engineering Framework (ASEF)
Background: Patients performing self-care in the unsupervised setting do not always adhere to the instructions they were initially provided with. As a consequence, a patient’s ability to successfully comply with the treatment plan cannot be verified by the treating healthcare professional, possibly resulting in reduced data quality and suboptimal treatment. Objectives: The aim of this paper is ...
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Increased vascular endothelial permeability and inflammation are major pathological mechanisms of pulmonary edema and its life-threatening complication, the acute respiratory distress syndrome (ARDS). We have previously described potent protective effects of hepatocyte growth factor (HGF) against thrombin-induced hyperpermeability and identified the Rac pathway as a key mechanism of HGF-mediate...
متن کاملAsef, a link between the tumor suppressor APC and G-protein signaling.
The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors. Here the APC gene product is shown to bind through its armadillo repeat domain to a Rac-specific guanine nucleotide exchange factor (GEF), termed Asef. Endogenous APC colocalized with Asef in mouse colon epithelial cells and neuronal cells. Furthermore, APC enhanced the GEF ...
متن کاملPhosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF.
Rac1 has a crucial role in epidermal growth factor (EGF)-induced membrane ruffling, lamellipodial protrusion, and cell migration. Several guanine nucleotide exchange factors (GEFs) including Sos1, Sos2, Tiam1 and Vav2 have been shown to transduce the growth signal from the EGF receptor to Rac1. To clarify the role of each GEF, we time-lapse imaged the EGF-induced activity change of Rac1 in A431...
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ژورنال
عنوان ژورنال: Afyon Kocatepe Üniversitesi Sosyal Bilimler Dergisi
سال: 2014
ISSN: 1302-1265
DOI: 10.5578/jss.7610